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DNA Sequence Nanochannel COMSOL Simulation Beads inside the pore Solidwork Pores

Welcome to the Integrative Biosensing Laboratory!

The IBL is a multidisciplinary research laboratory utilizing the cutting edge nanotechnologies and microfabrication techniques with the main focus on design and development of miniaturized biosensors and bio-platforms for point-of-care (POC) medical diagnostics, preventive and therapeutic medicine. We are particularly interested in detection of biomolecules such as nucleic acids, proteins and small molecules. In order to achieve this goal we are integrating the fundamental science with innovative engineering technologies.

IBL is well equipped with ultra low-noise instrumentation and microscopy for single molecule sensitivity detection and nano-sensing applications. We also have full access to the Ohio Center for Microfluidic Innovation (OCMI) and ERC Clean Room facility at UC.

Research Projects

Nanopore Sensors:

Nanopore-based sensors have been attractive tools for rapid, single molecule and reagent-free detection of small molecules in past few decades. We are fabricating and utilizing a variety of nanopores such as solid-state and biological pores for biomedical sensing applications. We have successfully established numbers of collaborations across the UC campus and worldwide to design and develop sensitive and robust nanopore detection platforms for studying biomolecular functions and particularly nucleic acid detection.

Point-of-Care Diagnostics:

Our goal is to develop point-of-care early diagnostic tools to improve the disease-related mortality rates and increase the successful chance of early medical treatment or preventive plans. To achieve this goal we have several projects in-line such as handheld, home-based, and wireless cancer detection platform; and non-invasive, wearable stress hormone detection scheme. By nature they are very interdisciplinary research projects which involve collaborators from UC Cancer Institute, UC School of Pharmacy and UC Applied Sciences and Engineering.

Recent News:

  • Prof. Esfandiari (chair) along with Prof. Harshita Kumari (co-chair) will be organizing the Nanoscience and Biotechnology session at the ACSCERM 2016 (Central Region of the American Chemical Society ) held in Cincinnati May 18-21, 2016.
  • Prof. Esfandiari attending and presenting her new collaborative research project with prof. Ian Papautsky at the Center for Advanced Design & Manufacturing of Integrated Microfluidics (CADMIM) held in University of California Irvine, Irvine CA Feb 17-18, 2016.
  • Prof. Esfandiari participated in the all-female, St. Ursula high-school Academy's Career opportunity day (Dec 4th, 2015) to discuss science and engineering career opportunities with students and encourage female students to pursue an advanced career in Science and Engineering.
  • Prof. Esfandiari attended the DARPA wait, what? The forum future technology meeting held in St. Louis, Sep 9th -11th, 2015.
  • Principle investigator (PI) Dr. Esfandiari and her collaborators: Prof. Kasting, Prof. Park, Prof. Heikenfeld and Prof. Boyce were awarded $125000 for the strategic collaborative research in skin science and technology from office of research at University of Cincinnati. For more information please visit the website.
  • Prof. Esfandiari mentored and sponsored two undergraduate students from Women in Science and Engineering (WISE) program to conduct research at the University of Cincinnati, during summer 2015.